糖基
立体选择性
糖基化
化学
催化作用
尿素
卤化物
有机化学
组合化学
立体化学
生物化学
作者
Meng-Man Wei,Yan Ma,Gao-Lan Zhang,Qin Li,De‐Cai Xiong,Xin‐Shan Ye
标识
DOI:10.1002/asia.202300791
摘要
Abstract The efficient synthesis of N ‐glycosides via direct N ‐glycosylation of amides/azacycles has been reported. The glycosylation of amides/azacycles with glycosyl halides in the presence of a catalytic amount of urea proceeded smoothly to provide the corresponding N ‐glycosylated amides or nucleosides in good to excellent yields with 1,2‐ trans ‐stereoselectivity. Moreover, by the addition of terpyridine, the 1,2‐ cis ‐stereoselectivity was achieved.
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