先天性淋巴细胞
生物
效应器
细胞生物学
免疫系统
免疫学
重编程
维甲酸
免疫
细胞
细胞培养
遗传学
作者
Nikhat Shaikh,Alex Waterhölter,Ann-Christin Gnirck,Martina Becker,Virginia Adamiak,Lena Henneken,Malte Wunderlich,Wiebke Hartmann,Lara Linnemann,Tobias B. Huber,Christian Krebs,Ulf Panzer,Richard M. Locksley,Christoph Wilhelm,Minka Breloer,Jan-Eric Turner
摘要
Adaptation of immune cells to tissue-specific microenvironments is a crucial process in homeostasis and inflammation. Here, we show that murine effector type 2 innate lymphoid cells (ILC2s) from various organs are equally effective in repopulating ILC2 niches in other anatomical locations where they adapt tissue-specific phenotypes of target organs. Single-cell transcriptomics of ILC2 populations revealed upregulation of retinoic acid (RA) signaling in ILC2s during adaptation to the small intestinal microenvironment, and RA signaling mediated reprogramming of kidney effector ILC2s toward the small intestinal phenotype in vitro and in vivo. Inhibition of intestinal ILC2 adaptation by blocking RA signaling impaired worm expulsion during Strongyloides ratti infection, indicating functional importance of ILC2 tissue imprinting. In conclusion, this study highlights that effector ILC2s retain the ability to adapt to changing tissue-specific microenvironments, enabling them to exert tissue-specific functions, such as promoting control of intestinal helminth infections.
科研通智能强力驱动
Strongly Powered by AbleSci AI