生物
免疫系统
多细胞生物
炎症
细胞生物学
纤维化
信号转导
转化生长因子
疾病
发病机制
免疫学
表型
细胞
癌症研究
遗传学
基因
病理
医学
作者
Joan Massagué,Dean Sheppard
出处
期刊:Cell
[Elsevier]
日期:2023-09-01
卷期号:186 (19): 4007-4037
被引量:39
标识
DOI:10.1016/j.cell.2023.07.036
摘要
The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity. TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury repair through coordinated effects on cell proliferation, phenotypic plasticity, migration, metabolic adaptation, and immune surveillance of multiple cell types in shared ecosystems. Defects of TGF-β signaling, particularly in epithelial cells, tissue fibroblasts, and immune cells, disrupt immune tolerance, promote inflammation, underlie the pathogenesis of fibrosis and cancer, and contribute to the resistance of these diseases to treatment. Here, we review how TGF-β coordinates multicellular response programs in health and disease and how this knowledge can be leveraged to develop treatments for diseases of the TGF-β system.
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