α-C–H functionalization of glycine derivatives under mechanochemical accelerated aging en route the synthesis of 1,4-dihydropyridines and α-substituted glycine esters

A novel accelerated aging cross dehydrogenative coupling of glycine esters/amides and various nucleophiles under metal-free and solvent-minimal conditions was developed, providing a sustainable strategy to the synthesis of 1,4-DHP and α-substituted glycine derivatives.