医学
唾液腺
全身疗法
免疫疗法
下调和上调
靶向治疗
头颈部
肿瘤科
内科学
癌症研究
病理
基因
癌症
生物
外科
乳腺癌
生物化学
作者
Alice N Weaver,Stephanie Lakritz,Divneet Mandair,Mark B. Ulanja,Daniel W. Bowles
出处
期刊:Head & neck
[Wiley]
日期:2023-03-01
卷期号:45 (5): 1315-1326
被引量:2
摘要
Salivary gland carcinomas (SGC) are a rare and variable group of head and neck cancers with historically poor response to cytotoxic chemotherapy and immunotherapy in the recurrent, advanced, and metastatic settings. In the last decade, a number of targetable molecular alterations have been identified in SGCs including HER2 upregulation, androgen receptor overexpression, Notch receptor activation, NTRK gene fusions, and RET alterations which have dramatically improved treatment outcomes in this disease. Here, we review the landscape of precision therapy in SGC including current options for systemic management, ongoing clinical trials, and promising future directions.
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