医学
危险系数
生殖系
种系突变
内科学
肿瘤科
前瞻性队列研究
队列
人口
遗传学
突变
置信区间
生物
基因
环境卫生
作者
Kun Zhao,Xuxiang Shen,Hongwei Liu,Zhennan Lin,Jianxin Li,Shufeng Chen,Fangchao Liu,Keyong Huang,Jie Cao,Xiaoqing Liu,Chong Shen,Ling Yu,Yingxin Zhao,Liancheng Zhao,Ying Li,Dongsheng Hu,Jiangfeng Huang,Xiangfeng Lu,Dongfeng Gu
出处
期刊：JAMA Cardiology
[American Medical Association]
日期：2024-01-10
卷期号：9 (3): 233-233
被引量：22
标识
DOI：10.1001/jamacardio.2023.5095
摘要
The genetic basis of coronary heart disease (CHD) has expanded from a germline to somatic genome, including clonal hematopoiesis of indeterminate potential (CHIP). How CHIP confers CHD risk in East Asian individuals, especially those with small clones (variant allele fraction [VAF] 0.5%-2%) and different genetic backgrounds, was completely unknown.
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