背景(考古学)
生物
炎症
功能(生物学)
利基
免疫系统
疾病
调节性T细胞
细胞生物学
T细胞
计算生物学
免疫学
生物信息学
医学
白细胞介素2受体
古生物学
生态学
病理
作者
Maike Becker,Sandra M. Dirschl,Martin G. Scherm,Isabelle Serr,Carolin Daniel
标识
DOI:10.1016/j.cmet.2023.12.019
摘要
Tissue regulatory T cells (Tregs) exert pivotal functions in both immune and metabolic regulation, maintaining local tissue homeostasis, integrity, and function. Accordingly, Tregs play a crucial role in controlling obesity-induced inflammation and supporting efficient muscle function and repair. Depending on the tissue context, Tregs are characterized by unique transcriptomes, growth, and survival factors and T cell receptor (TCR) repertoires. This functional specialization offers the potential to selectively target context-specific Treg populations, tailoring therapeutic strategies to specific niches, thereby minimizing potential side effects. Here, we discuss challenges and perspectives for niche-specific Treg targeting, which holds promise for highly efficient and precise medical interventions to combat metabolic disease.
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