Rapid Resolution of Atypical Hemolytic Uremic Syndrome by Eculizumab Treatment

Rapid Resolution of Atypical Hemolytic Uremic Syndrome by Eculizumab TreatmentAtypical hemolytic uremic syndrome (aHUS) is an extremely rare and life-threatening disorder.Typical HUS is often caused by Shiga toxin-positive Escherichia coli, while aHUS is caused by dysregulation of the alternative pathway of the complement system in association with genetic abnormalities or development of autoantibodies.Eculizumab, a humanized anti-complement 5 monoclonal antibody, is recommended for the treatment of aHUS, but its long-term safety and efficacy in pediatric patients remain under review.In this paper, we report a pediatric case of aHUS with anti-complement factor H autoantibodies, who was treated successfully with eculizumab.