2019年冠状病毒病(COVID-19)
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
病毒学
外显率
受体
冠状病毒
冠状病毒科
大流行
2019-20冠状病毒爆发
生物
医学
药理学
计算生物学
爆发
遗传学
基因
内科学
表型
传染病(医学专业)
疾病
标识
DOI:10.26355/eurrev_202009_23067
摘要
Objective ACE2 long served as the human gateway for multiple coronaviruses, including the currently pandemic This mini-review explores the potential of targeting ACE2 in blocking viral penetrance. Materials and methods PubMed search was conducted using the terms: coronaviridae, peptidyl-dipeptidase A, ACE2, SARS, and SARS-CoV-2. References of relevant articles were further screened by the author. Results Four main methods of blocking ACE2-mediated viral penetrance were identified: receptor blockage, receptor decoying, receptor shedding, and co-receptor inhibition. Conclusions Drugs that inhibit viral binding to ACE2 present a strong choice for the current, and if necessary, future outbreaks. Further research is needed to establish the clinical and pharmacological aspects of the identified candidate molecules.
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