光热治疗
细胞内
谷胱甘肽
激进的
催化作用
抗氧化剂
化学
癌症治疗
氧化应激
组合化学
生物物理学
纳米技术
材料科学
生物化学
癌症
酶
生物
遗传学
作者
Peijing An,Fengying Fan,Dihai Gu,Zhiguo Gao,Abul Monsur Showkot Hossain,Baiwang Sun
标识
DOI:10.1016/j.jconrel.2020.03.007
摘要
Tumor microenvironment (TME)-responsive nanoformulations that catalyze a cascade of intracellular redox reactions showed promise for tumor treatment with high specificity and efficiency. In this study, we report Cu2+-doped zeolitic imidazolate frameworks-coated polydopamine nanoparticles ([email protected]/ZIF-8 NPs) for glutathione-triggered and photothermal-reinforced sequential catalytic therapy against breast cancer. In the TME, the [email protected]/ZIF-8 NPs could initially react with antioxidant glutathione (GSH), inducing GSH depletion and Cu+ generation. Whereafter, the generated Cu+ would catalyze local H2O2 to produce highly toxic hydroxyl radicals (·OH) through an efficient Fenton-like reaction even in weakly acidity. Importantly, the PDA could exert excellent photothermal conversion effect to simultaneously accelerate GSH consumption and improve the Fenton-like reaction for further expanding the intracellular oxidative stress, which innovatively achieves a synergistic photothermal-chemodynamic therapy for highly efficient anticancer treatment.
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