Similarities and interactions between GABAergic and glutaminergic systems.

Harmonious interactions between neurotransmitter systems are important for regulating the activity in the central nervous system (CNS). gamma-Aminobutyric acid (GABA) and glutamate (Glu) are major inhibitory and excitatory neurotransmitters in the mammalian central nervous system. Neuronal excitability, probably synaptic plasticity, cognitive performance, learning and memory processes frequently the results of the balance of GABAergic inhibitory and glutaminergic excitatory inputs.