Long Term Curative Effect of Recombinant Human B-Type Natriuretic Peptide on Acute Decompensated Heart Failure

Objective To investigate the long term curative effect of recombinant human B-type natriuretic peptide(rhBNP) on acute decompensated heart failure(ADHF).Methods A total of 107 patients characterized of acute exacerbation of chronic heart failure were enrolled in this randomized,open-label,parallel-design study.Then the patients were divided into rhBNP group(40 cases) and standard therapy group(67 cases).Both groups received the conventional treatment for heart failure,while the rhBNP group was given additional nesiritide.According to the results of six months follow-up to evaluate the cut-off level of NT-proBNP decrease when patients without ADHF during the clinical follow-up,and the survival analysis was done in patients without ADHF during the clinical follow-up in both groups.Results In the surviving patients without ADHF after hospital discharge,the cumulative survival rate of patients with NT-proBNP decrease rate more equal than 35% was higher than that less than 35%(P=0.001),The mean cumulative survival in rhBNP group was extremely higher than that in standard therapy group(P=0.021).Conclusion The cumulative survival of survivals without ADHF during the clinical follow-up in rhBNP group is better than that in standard therapy group,and NT-proBNP decreased-level≥35% has the highest cumulative survival of survivals without ADHF.