A core-shell nanosensor was fabricated by molecular self-assemble and evaporation technique in this paper. The optical property of that was measured based on the detection system of LSPR. The sensitivity of this core-shell nanosensor is 300nm/RIU and the decay length is 26nm based LSPR detection system. The results show that this nansensor can reach high sensitivity and be applied for the small molecule or low concentration detection.