Objective To approach the importance of selecting accurate drug targets for new drug research and investigation.Methods In this article,G protein-coupled receptors,growth factor receptors,ionophorous proteins and nuclear receptors were taken as examples to introduce the screening and recognition of drug targets based on the latest 21 references.Some representative drugs screened on the plate were also reported.Results and Conclusions As an accompaniment of the rapid progress of molecular genetics,functional genomics,proteomics and bioinformatics,more and more biology molecules with distinct functions have been found.Some genes or their productions have become drug targets due to that their confirmed relationship with disease's occurrence or development.It is very important to choose drug targets for new drug research and investigation.