【Objective】To summarize the method and clinical result of repairing traumatic peripheral arterial defect by Polytetrafluoroethylene(ePTFE) blood vessel graft,discuss the way of preventing the infection of vessel anastomosis.【Methods】Forty cases with traumatic peripheral arterial defect were repaired with ePTFE blood vessel grafting or bypass reconstruction.【Results】The results of the blood flow in grafted vessel was satisfactory and blood circulation at distal part of the extremities was good.The follow-up ranged from 6 months to 2 years,the primary patency rates of 100%、96.9%、89.3%.were observed in 6 months、1 year、2 years respectively.No case was amputated.【Conclusion】Repairing the traumatic peripheral arterial defect with ePTFE blood vessel graft is a safe and convenient technique in clinical practice.It can be an alternative method to solve the difficult source and limited diameter of autovessels in the body.