The effect diltiazem on aged unstable angina patients

OBJECTIVE To investigate the clinical therapeutic effect and safety of diltiazem to treat unstable angina(UA) of old people by continuous intravenous injection.METHODS 26 aged UA patients who did not get well with the glyceryl trinitrate therapy accepted the continuous intravenous injection of diltiazem with a dosage of 30mg.The initial dosage was 1μg/(kg·min)~(-1),if the effect was not obvious,the dosage would be increased to 3μg/(kg·min)~(-1) ~5μg/(kg·min)~(-1).When the symptom was relieved,the effective dosage was maintained to 48h,then 30mg(tif) of diltiazem tablets was given.The angina symptom,ECG and the hemodynamics changes were observed during the process. RESULTS The advent frequency of angina during the 72 hours before therapy was(5.26±2.57),while the symptom relieved after the diltiazem injection for an average of(9.2±6.8) minutes.Among them 7 patient's angina did not get controlled until the dosage was adjusted to 5μg/(kg·min)~(-1).Compared with the 72 hours before therapy,the angina frequency descended after the injection for 48 hours and the duration of angina got decreased.3 patients got normal ST and T waves after injection and 6 patients recovered obviously.Their blood pressures and heart rates decreased after therapy(P0.05) and no adverse-effects such as AMI and death occurred.CONCLUSION It is an effective therapy of continuous diltiazem intravenous injection to the aged UA patients whose symptoms can not be relieved after given of glyceryl trinitrate.