The Synthesis of N-substituted Derivatives of Phthalimides under PTC

Michael addition of phthalimides to (C)(C) double bond compounds having electron withdrawing group in the α-position under PTC condition is described. Eight compounds,such as N-phthalyl-β-alanine butyl ester and β-(4-nitrophthalimido),in which N-substituted derivatives of phthalimides serving as building blocks, were synthesized by this convenient method. Their structures were identified by means of IR, EA, and ()~1H NMR.