Objective To explore the effect of extracts of barley on lowering serum lipid in hyperlipidemia population. Methods Totally 106 hyperlipidemia volunteers were randomly divided into test group and control group according to contents of serum lipid.The volunteers in test group were orally administered with extracts of barley on 45 successive days.Before and after the test,serum total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C) and the indexes of safety were determined. Results After the test,the levels of TC and TG in test group decreased significantly,and the decreasing rates of TC and TG were 10.64% and 16.65%,respectively.After the test,there were statistically significant differences in the levels of TC and TG between control group and test group,also between before and after the test in test group.The level of HDL-C was increased by 0.11 mmol/L,and there was no statistically significant difference between test group and control group(P0.05).No significant change was found in all the indexes of safety before and after the test. Conclusions Extracts of barley has serum lipid-lowering effects in hyperlipidemia population.