Electrochemical non-enzymatic glucose sensors based on nano-composite of Co3O4 and multiwalled carbon nanotube

Nanocomposite of Co3O4 and multiwalled carbon nanotube (MCNT) was synthesised using one step solvothermal method, and an electrochemical non-enzymatic glucose sensor (Co3O4-MCNT/GCE) was successfully constructed by a dropping method. The obtained Co3O4 and Co3O4- MCNT were characterized and investigated by transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDS). Quantitative analysis of glucose was performed using the amperometric (i–t) method, and plot of current difference versus concentration of glucose was linear in the range of 1.0–122 μmol/L, with a linear correlation coefficient (R2) of 0.9983 and limit of detection (LOD) of 0.28 μmol/L. Sensitivity of this sensor was evaluated as 2550 μA L mmol−1 cm−2. This new sensor produced satisfactory reproducibility and stability and was applied to monitor trace amounts of glucose in human serum samples.