The NLRC4 inflammasome requires IRF8-dependent production of NAIPs

The NLRC4 inflammasome requires IRF8-dependent production of NAIPs – Inflammasomes orchestrate cellular responses to pathogen- or danger-associated molecular patterns by controlling the activation of caspase-1. Inflammasome activation results in enzymatically active caspase-1, which mediates the maturation and release of the pro-inflammatory cytokines IL-1β and IL-18 and induces a form of inflammatory cell death termed pyroptosis. The NLRC4 inflammasome is crucial for protection against infection (...)