癌变
转染
生物
互补DNA
分子生物学
细胞凋亡
癌症研究
肝细胞癌
基因
微阵列
寡核苷酸
基因表达
遗传学
作者
Hiroshi Okabe,Seiji Satoh,Yoichi Furukawa,Tatsushi Kato,Suguru Hasegawa,Yumi Nakajima,Yoshio Yamaoka,Yusuke Nakamura
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2003-06-15
卷期号:63 (12): 3043-8
被引量:67
摘要
Through a genome-wide cDNA microarray, we identified that the paternally expressed gene 10 (PEG10) was highly expressed in a great majority of hepatocellular carcinomas, although its expression was absent in normal liver cells. Exogenous expression of PEG10 conferred oncogenic activity and transfection of hepatoma cells with antisense S-oligonucleotides suppressing PEG10 resulted in their growth inhibition. Additional experiments revealed that PEG10 protein associated with SIAH1, a mediator of apoptosis, and that overexpression of PEG10 decreased the cell death mediated by SIAH1. These findings suggested that development of drug(s) inhibiting PEG10 activity could be a novel approach for the treatment of hepatocellular carcinomas.
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