遗产管理(遗嘱认证法)
干扰素
γ干扰素
免疫学
医学
病毒学
干扰素γ
细胞因子
政治学
法学
作者
Bruno Gran,Niansheng Chu,Guang‐Xian Zhang,Shuo Yu,Yonghai Li,Xiaohan Chen,Malek Kamoun,Abdolmohamad Rostami
标识
DOI:10.1016/j.jneuroim.2004.07.019
摘要
Abstract
Recent findings have shown that IL-12, a key inducer of Th1 cell development, is not required in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) as severe CNS inflammatory demyelination can develop in the absence of IL-12 or IL-12 responsiveness. These data raised the possibility of an immunomodulatory action of IL-12 in this disease model. We show here that IL-12 suppresses MOG35–55-induced EAE in the C57BL/6 mouse when administered during the early induction phase of the disease. The inhibitory effect is interferon-γ-(IFN-γ)-dependent, as clearly shown by lack of suppression in IFN-γ-deficient mice, and is also accompanied by inhibition of mRNA expression of the proinflammatory cytokine IL-17.
科研通智能强力驱动
Strongly Powered by AbleSci AI