Janus激酶1
SOCS3
细胞因子
细胞因子信号抑制因子
贾纳斯激酶
细胞因子信号抑制因子1
SOCS2
细胞因子受体
生物
信号转导
细胞生物学
斯达
受体
SOCS5型
转录因子
基因剔除小鼠
表型
免疫学
糖蛋白130
抑制器
白细胞介素6
遗传学
车站3
基因
作者
Massimo Gadina,Douglas J. Hilton,James A. Johnston,Akio Morinobu,Arash Lighvani,Yongjie Zhou,Roberta Visconti,John J. O’Shea
标识
DOI:10.1016/s0952-7915(00)00228-4
摘要
Discovered during the past ten years, Janus kinases and signal transducers and activators of transcription have emerged as critical elements in cytokine signaling and immunoregulation. Recently, knockout mice for all the members of these families have been generated, with remarkably specific outcomes. Equally exciting is the discovery of a new class of inhibitors, the suppressor of cytokine signaling family. The phenotypes of mice deficient in these molecules are also striking, underscoring the importance of negative regulation in cytokine signaling.
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