代谢物
脱氨基
化学
氯胺酮
新陈代谢
天然产物
立体化学
尿
生物化学
色谱法
药理学
生物
酶
神经科学
作者
Isaac Lai,Suk‐Chang Hong,John N. Davisson
标识
DOI:10.1002/jps.2600740425
摘要
During attempts to synthesize 2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone (6), a ketamine metabolite, an unexpected product, 3-(2-chlorophenyl)-2-hydroxy-2-cyclohexenone (4) was obtained as the major product. This compound apparently was formed by rearrangement and deamination of 6 during the isolation and purification procedures. This same compound was found in plasma and urine extracts obtained from mice and rats that had been treated with either ketamine or norketamine. It is suggested that 3-(2-chlorophenyl)-2-hydroxy-2-cyclohexenone (4), isolated from these biological samples, probably arose from decomposition of the 6-hydroxylated metabolite of ketamine or norketamine and is itself not a true metabolite.
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