分子识别
互补性(分子生物学)
寄主(生物学)
化学
结合位点
分子模型
立体化学
计算生物学
分子
生物
生物化学
生态学
遗传学
有机化学
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1988-05-06
卷期号:240 (4853): 760-767
被引量:417
标识
DOI:10.1126/science.3283937
摘要
The origins, definitions, tools, and guiding principles of host-guest chemistry are developed. Perching, nesting, and capsular complexes are exemplified through molecular model and crystal structure comparisons. The degree of preorganization of a host for binding is a central determinant of its binding power. Complementarity of binding site placement in host and guest is a central determinant of structural recognition in complexation. Examples are given of chiral recognition in complexation, of partial transacylase mimics, of caviplexes, and of a synthetic molecular cell.
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