全合成
立体化学
戒指(化学)
不对称碳
组合化学
化学
有机化学
光学活性
作者
Teruaki Mukaiyama,Isamu Shiina,Hayato Iwadare,Masahiro Saitoh,Toshihiro Nishimura,Naoto Ohkawa,Hiroki Sakoh,Koji Nishimura,Yu‐ichirou Tani,Masatoshi Hasegawa,Koji Yamada,Katsuyuki Saitoh
标识
DOI:10.1002/(sici)1521-3765(19990104)5:1<121::aid-chem121>3.0.co;2-o
摘要
A new method for the total asymmetric synthesis of antitumor agent Taxol is described. Baccatin III, a complex carbon framework, is synthesized by way of B to BC to ABC ring construction. Further, a method of forming Taxol from baccatin III and a β-amino acid is also demonstrated.
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