串扰
生物
多细胞生物
细胞生物学
磷脂酰肌醇
PI3K/AKT/mTOR通路
激酶
信号转导
遗传学
基因
物理
光学
作者
Jeffrey A. Engelman,Ji Luo,Lewis C. Cantley
摘要
Phosphatidylinositol 3-kinases (PI3Ks) evolved from a single enzyme that regulates vesicle trafficking in unicellular eukaryotes into a family of enzymes that regulate cellular metabolism and growth in multicellular organisms. In this review, we examine how the PI3K pathway has evolved to control these fundamental processes, and how this pathway is in turn regulated by intricate feedback and crosstalk mechanisms. In light of the recent advances in our understanding of the function of PI3Ks in the pathogenesis of diabetes and cancer, we discuss the exciting therapeutic opportunities for targeting this pathway to treat these diseases.
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