Sub-Therapeutic Levels of Oral Tacrolimus Prophylaxis Prior to Allogeneic Stem Cell Transplant Do Not Predict the Incidence of Chronic Graft Versus Host Disease

Chronic graft versus host disease (cGVHD) is a common complication of allogeneic stem cell transplantation (ASCT). Tacrolimus prophylaxis has been proven to be instrumental in the prevention of acute graft versus host disease (aGVHD) a common precursor to developing cGVHD. Our institution uses oral tacrolimus prior to ASCT because we perform ASCT in the outpatient setting and increases ease of administration. We retrospectively reviewed our experience in 94 consecutive patients (pts) who received ASCT from 10 /10 HLA matched donors, 47 were matched sibling donors (MSD) and 47matched unrelated donors (MUD) with a median age of 50 and 52 respectively.