组蛋白甲基化
组蛋白甲基转移酶
生物
组蛋白
EZH2型
表观遗传学
甲基转移酶
DNA甲基化
表观遗传学
甲基化
遗传学
基因表达
基因
作者
Chunyan Liu,Falong Lu,Xia Cui,Xiaofeng Cao
标识
DOI:10.1146/annurev.arplant.043008.091939
摘要
Histone methylation plays a fundamental role in regulating diverse developmental processes and is also involved in silencing repetitive sequences in order to maintain genome stability. The methylation marks are written on lysine or arginine by distinct enzymes, namely, histone lysine methyltransferases (HKMTs) or protein arginine methyltransferases (PRMTs). Once established, the methylation marks are specifically recognized by the proteins that act as readers and are interpreted into specific biological outcomes. Histone methylation status is dynamic; methylation marks can be removed by eraser enzymes, the histone demethylases (HDMs). The proteins responsible for writing, reading, and erasing the methylation marks are known mostly in animals. During the past several years, a growing body of literature has demonstrated the impact of histone methylation on genome management, transcriptional regulation, and development in plants. The aim of this review is to summarize the biochemical, genetic, and molecular action of histone methylation in two plants, the dicot Arabidopsis and the monocot rice.
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