Short Oxo–Titanium(IV) Bond in Bacterial Transferrin: A Protein Target for Metalloantibiotics

A competitive edge? TiIV binding to a bacterial transferrin (ferric-ion-binding protein, FBP; see picture, foreground) is rapid, competes with FeIII binding, and results in a short oxo–TiIV bond (EXAFS studies; see picture, background). Inhibitors of iron uptake by FBP should be active against diseases caused by bacterial pathogens. The results suggest that Ti complexes could provide such inhibition. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600260_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.