体内
胶质瘤
对比度(视觉)
磁共振成像
核磁共振
荧光
化学
医学
放射科
癌症研究
物理
光学
生物
生物技术
作者
Meser M. Ali,Mohammed Bhuiyan,Branislava Janic,Nadimpalli Ravi S. Varma,Tom Mikkelsen,James R. Ewing,Robert A. Knight,Mark Pagel,Ali S. Arbab
出处
期刊:Nanomedicine
日期:2012-12-01
卷期号:7 (12): 1827-1837
被引量:35
摘要
Aim: The authors have investigated the usefulness of in vivo chemical exchange saturation transfer MRI for detecting gliomas using a dual-modality imaging contrast agent. Materials & methods: A paramagnetic chemical exchange saturation transfer MRI contrast agent, Eu-1,4,7,10-tetraazacclododecane-1,4,7,10-tetraacetic acid-Gly 4 and a fluorescent agent, DyLight ® 680, were conjugated to a generation 5 polyamidoamine dendrimer to create the dual-modality, nano-sized imaging contrast agent. Results: The agent was detected with in vivo chemical exchange saturation transfer MRI in an U87 glioma model. These results were validated using in vivo and ex vivo fluorescence imaging. Conclusion: This study demonstrated the merits of using a nano-sized imaging contrast agent for detecting gliomas and using a dual-modality agent for detecting gliomas at different spatial scales. Original submitted 9 January 2012; Revised submitted 18 April 2012; Published online 14 August 2012
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