Taurine, a major amino acid of oyster, enhances linear bone growth in a mouse model of protein malnutrition

牛磺酸 生长因子 内科学 内分泌学 骨生长 氨基酸 化学 Janus激酶2 状态5 胰岛素样生长因子 贾纳斯激酶 STAT蛋白 信号转导 生物 生物化学 车站3 受体 医学
作者
Phil‐Dong Moon,Min‐Ho Kim,Hun‐Sun Lim,Hyun‐A Oh,Sun‐Young Nam,Na‐Ra Han,Myong Jo Kim,Hyun‐Ja Jeong,Hyung‐Min Kim
出处
期刊:Biofactors [Wiley]
卷期号:41 (3): 190-197 被引量:32
标识
DOI:10.1002/biof.1213
摘要

Oysters (Oys) contain various beneficial components, such as, antioxidants and amino acids. However, the effects of Oys or taurine (Tau), a major amino acid in Oys on bone growth have not been determined. In the present study, we evaluated the effects of Oys or Tau on linear bone growth in a mouse model of protein malnutrition. To make the protein malnutrition in a mouse, we used a low protein diet. Growth plate thickness was increased by Oys or Tau. Bone volume/tissue volume, trabecular thickness, trabecular number, connection density, and total porosity were also improved by Oys or Tau. Oys or Tau increased insulin-like growth factor-1 (IGF-1) levels in serum, liver, and tibia-growth plate. Phosphorylations of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) were increased by Oys and by Tau. These findings show that Oys or Tau may increase growth plate thickness by elevating IGF-1 levels and by promoting the phosphorylations of JAK2-STAT5, and suggest that Oys or Tau are growth-promoting substances of potential use in the food and pharmaceutical industries.
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