相互作用体
蛋白质折叠
折叠(DSP实现)
蛋白质组
计算生物学
生物
化学
蛋白质结构
大肠杆菌
基因
生物化学
电气工程
工程类
作者
H. Eric Xu,Cheng Junfeng,Xiao-Pan Hu,Ying-ying Chu,Bin-Guang Ma
标识
DOI:10.1007/s00726-016-2309-x
摘要
Protein in protein-protein interaction network are especially important due to their central roles in the entire network. Despite of their importance, the folding kinetics of proteins in comparison with non-hubs is still unknown. In this work, the folding rates for protein and non-hubs were predicted and compared for the interactome of Escherichia coli K12, and the results showed that proteins fold faster than non-hub proteins. A possible explanation might be that protein have more and fast-folding structural conformations than non-hubs, which leads to the notion of hub of hubs in the protein conformation space. It was found that the sequence and structure features relevant to protein folding rates are also different between and non-hub proteins. Moreover, the interacting proteins tend to have similar folding rates. These results gave insightful implications for understanding the interplay between the mechanisms of protein folding and interaction.
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