化学
催化作用
钨酸盐
硫酸化
醋酸铵
氨
亲核细胞
有机化学
酰胺
腈
亲核加成
反应条件
药物化学
区域选择性
组合化学
三甲硅基氰化物
高效液相色谱法
生物化学
作者
Sachin D. Veer,Kamlesh V. Katkar,Krishnacharya G. Akamanchi
标识
DOI:10.1016/j.tetlet.2016.07.073
摘要
An efficient and mild method for the synthesis of amidines by direct nucleophilic addition of amines to nitriles using sulfated tungstate as heterogeneous catalyst is described. Highlight of the method is its applicability for the synthesis of amidines using a wide variety of amines including ammonia as ammonium acetate and nitriles. Catalyst is mildly acidic, stable, easy to prepare and separate from the reaction mass.
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