The effect of low-frequency r-TMS to anxiety-depression in patients with acute phase of cerebral infarction

Objective:To study the effect of low-frequency r-TMS to anxiety-depression and ability of activities of daily living(ADL)in patients with acute cerebral infarction. Method:According to be selected standard,65 acute cerebral infarction patients were divided randomly into 2 groups:control group (32 cases) treated with routine therapy only,and therapy group(33cases) received routine therapy and r-TMS for 8 weeks.Patients were evaluated with scores of Hamilton anxiety rating scale(HAMA),Hamilton depression(HAMD)and Chinese stroke scale(CSS)and modified Barthel index(MBI)before and after treatment. Result:After treatment, in control group the scores of HAMA, HAMD and CSS decreased by 13.33%, 13.13% and 20.62% respectively,of which the scores of psycho-anxiety and somato-anxiety decreased by 11.71% and 15.30%, and the scores of MBI elevated by 40.85% (all P0.05); in therapy group the scores of HAMA, HAMD and CSS decreased by 33.60%, 35.66% and 26.23% respectively,of which the scores of psycho-anxiety and somato-anxiety decreased by 34.64% and 20.26%, and the scores of MBI elevated 40.10% (all P0.05). Otherwise, after treatment the scores of HAMA, psycho-anxiety, HAMD and CSS in therapy group decreased more significantly than those in control group(P0.05), but the decrease of somato-anxiety and rise of MBI had no significant difference in two groups (P0.05). The total effective rate of anxiety in therapy group (78.95%) was higher than (P0.05) that in control group (12.00%), and for depression were 86.96% to 9.52% respectively (P0.05). Conclusion:Low-frequency r-TMS applied in patients with acute cerebral infarction could improve anxiety-depression, especially psycho-anxiety symptom and decrease neurologic impairment, but it had less impact on ability of ADL.