Objective To explore the prevalence state of endemic fluorosis associated with and evaluate control effects in Shaanxi. Methods By stratified sampling, dental fluorosis in children aging 8~12 years and skeletal fluorosis in adults aging above 16 years were examined. X-Ray films were taken in subjects with suspicious skeletal fluorosis. Fluoride levels in drinking water and children's urine were determined. Results In 20 counties, the dental fluorosis rate was 38.64%, and 75.56% in severe fluorosis areas. The skeletal fluorosis rate were 11.76%, and 31.73% in the severe fluorosis areas. The positive rate of X-Ray detection was 63.61%. The fluoride levels in 62.96% of water samples exceeded criterion established by the Ministry of Health of the People's Republic of China. The fluoride levels in 55.15% of water samples of over-criterion were beyond 2.1 mg/L. The median of fluoride levels in children's urine was 2.00 mg/L, and 4.58 mg/L in the severe fluorosis areas. As compared with 1980, the dental fluorosis rate descended in varying degrees in 85% of 20 counties, among which 5 counties had become non-endemic fluorosis areas. Average decreased ranges of the dental fluorosis rate reached 46.14% in 20 counties. Conclusions The prevalence of endemic fluorosis associated with drinking water is comparatively serious in Shaanxi. Prophylactic measures, such as improving water quality, have achieved great results.