Rheumatoid arthritis is a common disabling diease,seriously affecting the patients' quality of life.Traditional drugs treatment for rheumatoid arthritis include nonsteroid anti-inflammatory drugs,corticosteroids,and disease modifying antirheumatic drugs,however,these drugs are often not satisfied to control the condition of refractory rheumatoid arthritis,and resulting in severe joint damage.Recently,the emergence of multiple biological agents brought hope to the treatment of refractory rheumatoid arthritis patients.These agents play an important role in the control of rheumatic conditions and the improvement of quality of life in RA patients.