Clinical analysis of 22 cases of pregnancy complicated with hyperthyroidism

Objective To study the changes of thyroid function of pregnancy complicated with hyperthyroidism during gestation and the influence on the outcome of their pregnancies. Methods Clinical data of 22 cases of pregnancy complicated with hyperthyroidism from 1993 to 1998 were analyzed retrospectively.Results In these 22 cases, 14 had overt clinical symptoms, including 3 primary cases, 8 recurrent and 3 aggravated ones, 5 cases (35.71%) occurred in early gestation, 9 (64.29%) in later gestation, 3 cases (21.43%) during premature labor, 6 with (42.86%) IUGR, 4 (28.57%) with placenta dysfunction, 4 (28.57%) with neonatal asphyxia, 1 each with (7.14%) neonatal hyperthyroidism, neonatal hypothyroidism and low weight. The thyroid function of the remaining 8 cases showed no changes. Conclusion The symptoms of hyperthyroidism can be induced, recurred or worsened during every gestation, especially in the middle and late gestations. Pregnancy complicated with hyperthyroidism can result in bad outcome of pregnancy, in particular, the effect on the fetus and the neonate. Hence,they should be treated early and monitored in follow up.