The role of Ulinastatin in management of systemic inflammatory response syndrome post-CPB

Objective The article aims to investigate the utility of Ulinastatin(UTI) in inhibition of systemic inflammatory response syndrome (SIRS) and its protective effect on major organs during the post-CPB period. Methods 24 patients undergoing cardiac operation using CPB were divided into two groups randomly, according to receiving UTI injection or not. Their manifestation of SIRS, index of homodynamic and respiratory function and data of the early recovery were retrospectively analyzed. Results The respective serum concentration of TNF-α, IL-1, IL-6, and IL-8 in UTI group was lower than in the control group obviously. There were significant differences in the cardiac index (CI), stroke index (SI) and oxygen index (OI) between the two groups. All the patients fully recovered their health after the operation. The period of ventilatory support and the ICU days in UTI group were shorter than in the control group, while there were no statistically differences in total cost of hospitalization between two groups. Conclusion An injection of UTI can inhibit the elevation of proinflammatory cytokines, thus improve the postoperative recovery of patients without any complications.