In this paper,the stress analyses of internal pressure vessels with the same diameter opening were carried out by using ANSYS and SHELL63.And the stress distribution rules near the nozzle locations were derived.A group of relevant formulas of stress concentration factors(SCF) about the edge of the hole were obtained.The result showed that only using SCF to judge the maximum stress value is unreasonable.The engineering application showed that the finite element analysis soft ware was good at solving the equipment large opening.It also provided some important references for designing appropriate structures and using safely under a certain condition.