Prevention of coronary artery restenosis by local ~ (32) phosphate irradiation in swine

Objective:To evaluate efficacy,feasibility and safety of 32 P liquid filled balloon irradiation in preventing restenosis in swine.Methods:After overstretch balloon angioplasty injury,the left anterior descending branch(LAD) of coronary artery was treated with 32 P or control 35 days later ,the morphometry and histopathologic analyses were carried out in the injured segments.Results:The lumen area was significantly larger ( P 0 01) while the neointima area( P 0 01),percent area stenosis ( P 0 01) and PCNA positive cells ( P 0 01) reduced sighificantly in the radiotherapeutic animals than in the control animals. Conclusion:The approach was safe,effective and feasible in preventing restenosis.