小RNA
食管
医学
疾病
癌
内科学
肿瘤科
癌症研究
生物
病理
基因
遗传学
作者
Tomoyuki Okumura,Yutaka Shimada,Tetsuya Omura,Katsuhisa Hirano,Takuya Nagata,Kazuhiro Tsukada
出处
期刊:PubMed
日期:2015-02-01
卷期号:35 (2): 719-27
被引量:16
摘要
Small cell carcinoma of the esophagus (SCCE) is a rare but very aggressive disease with poor prognosis. The aim of the present study was to identify a molecular signature to predict postoperative outcomes in patients with SCCE.Expression of microRNA was detected in surgically-removed SCCE tumors using microarrays. A SCCE cell line (TYUC-1) was established to investigate the biological role of differentially expressed microRNAs.Hierarchical clustering of microRNA expression revealed two discrete clusters that were identical to the cases with rapid tumor relapse (n=3; median survival, 5.1 months) and the cases with long-term survival (n=3; median observation, 144.7 months), respectively. Eight microRNAs (miR-4323, miR-625, miR-3619-3p, miR-4419b, miR-1249, miR-4648, miR-4664-3p and miR-1203) showed significant correlation with tumor relapse (p<0.01). Migration of TYUC-1 was significantly inhibited by down-regulation of miR-625.The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE.
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