Comparison determination of glutaraldehyde concentration between potentiometric titration and manual titration

Objective:It will use potentiometric titration to determine the glutaraldehyde concentration in disinfection and sterilization agent,and compare with manual titration of the acid-base titration.Methods: With 0.25 mol/L sulfuric acid solution as the standard titration solution,it will respectively use potentiometric titration and acid-base titration to determine glutaraldehyde concentration in disinfection and sterilization agent,and also use the outcome to calculate the coefficient of variation and establish the linear regression equation.Results: When glutaraldehyde concentration is between 2.0% and 2.2%,the reaction of the two methods is stable in 60～90 min.the coefficient of variation of potentiometric titration(0.08%)is significantly lower than manual titration(0.60%),when glutaraldehyde concentration determined by potentiometric titration is between 2.0% and 2.2% it is highly relevant with sulfuric acid titration solution(r=1).Conclusion: It has several advantages,such as easy to judge the endpoint,little error,high precision and so on,when using potentiometric titration to determine glutaraldehyde concentration in disinfection and sterilization agent.It is worth to spread.