Structures and anti-histamine activities of phenolic acid derivatives from Bidens parviflora Willd.

Aim To find biological active compound from Bidens parviflova Willd on the basis of its activities against histamine release.Methods The chemical constituents from Bidens parviflora Willd.were isolated by silica gel column chromatography,Sephadex LH-20 column chromatography and purified by preparative HPLC.The chemical structures were identified by physical,chemical properties and spectroscopic methods.Results Six isolated phenolic acid derivatives were identified as quinic acid(1),caffeic acid(2),2,3,4-trihydroxy-isovaleric acid-2(3),protocatechuic acid(4),p-hydroxycinnamic acid(5),3,5-di-[1-O-(5-caffeoyl)-quinic acid]-4-caffeoylquinic acid(6).Conclusion Compound 6 is a new compound.Some of the six compounds exhibite activities against histamine release.