纳米棒
材料科学
纳米纤维
前药
纳米技术
生物相容性
药物输送
药品
纳米结构
肽
PEG比率
结合
自组装
生物物理学
药理学
生物化学
化学
生物
经济
冶金
数学分析
数学
财务
作者
Rui Chen,Jingjing Wang,Chen Qian,Yujie Ji,Chenlu Zhu,Li Wu,Weidong Li,Xiaolin Bi,Yutong Wang,Gang Cao,Zhipeng Chen
标识
DOI:10.1002/adfm.201806058
摘要
Abstract Peptide‐drug conjugates (PDCs) are a type of self‐assembled prodrug with good potential for drug delivery due to their excellent biocompatibility, high drug loading, and permanent controllable release. However, most PDCs tend to self‐assemble into filamentous nanostructures in water and under physiological conditions, making them unsuitable as intravenous formulations due to the entanglement of long fibers and the risk of thrombus. Injected PDCs also face challenges in overcoming the complex physiological environment to reach the target site. To expand their clinical use, it is necessary to control the properties of PDC, including the self‐assembled structure and physiological performance, to avoid the above problems. Based on assembly mechanism studies of PDCs, a new method for regulating PDC morphology is developed by controlling intermolecular interactions in the assembly process. This method can alter the final morphology of PDCs from nanofibers to nanorods, and the introduced macromolecules endow the PDC with new characteristics that facilitate stable and high‐efficiency access to the target site.
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