免疫系统
巨细胞病毒
病毒学
免疫学
逃避(道德)
免疫
生物
dna疫苗
杀菌剂
人巨细胞病毒
病毒
医学
免疫
疱疹病毒科
病毒性疾病
人类免疫缺陷病毒(HIV)
作者
Naoki Inoue,Mao Abe,Ryo Kobayashi,Souichi Yamada
标识
DOI:10.1007/978-981-10-7230-7_13
摘要
The development of a cytomegalovirus (CMV) vaccine has become a top priority due to its potential cost-effectiveness and associated public health benefits. However, there are a number of challenges facing vaccine development including the following: (1) CMV has many mechanisms for evading immune responses , and natural immunity is not perfect, (2) the immune correlates for protection are unclear, (3) a narrow range of CMV hosts limits the value of animal models, and (4) the placenta is a specialized organ formed transiently and its immunological status changes with time. In spite of these limitations, several types of CMV vaccine candidate, including live-attenuated, DISC , subunit, DNA, vectored, and peptide vaccines, have been developed or are currently under development. The recognition of the pentameric complex as the major neutralization target and identification of various strategies to block viral immune response evasion mechanisms have opened new avenues to CMV vaccine development. Here, we discuss the immune correlates for protection, the characteristics of the various vaccine candidates and their clinical trials, and the relevant animal models.
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