荧光
硫化氢
化学
体内
光化学
香豆素
胺气处理
量子产额
赫拉
硫化物
斑马鱼
选择性
组合化学
体外
生物化学
有机化学
催化作用
硫黄
生物技术
物理
基因
生物
量子力学
作者
Yan Sun,Chen Li,Xiaowei Feng,Chuanfeng Wang,Ning Wang,Junru Zhu,Ting Wang,Xiaoyan Cui
标识
DOI:10.1016/j.dyepig.2020.109059
摘要
Fluorescent probes with high sensitivity, selectivity, and fast response are urgently required for fluorescent imaging. The introduction of silicon atom into coumarin skeleton have resolved abrupt and instant increment in fluorescent quantum yield (from 0.002 into 0.93) when the 3-azide was reduced to 3-amine. The hydrogen sulfide triggered reduction process has ultrafast kinetic and reached equilibrium within 25 s. A group of silicon substituted coumarins SiC-Azs were designed for sensitively monitoring cellular hydrogen sulfide in vivo. The probe SiC-Az2 can be highly selective and sensitive to monitor endogenous and exogenous hydrogen sulfide in Hela cells and zebrafish.
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