胰高血糖素样肽-1
餐后
葡萄糖稳态
分泌物
肽
肽YY
激素
肽类激素
胰岛素
糖尿病
2型糖尿病
生物
内分泌学
内科学
医学
神经肽
胰岛素抵抗
生物化学
受体
神经肽Y受体
作者
Fiona M. Gribble,Frank Reimann
标识
DOI:10.1038/s42255-020-00327-x
摘要
Glucagon like peptide-1 (GLP-1), a peptide hormone from the intestinal tract, plays a central role in the coordination of postprandial glucose homeostasis through actions on insulin secretion, food intake and gut motility. GLP-1 forms the basis for a variety of current drugs for the treatment of type 2 diabetes and obesity, as well as new agents currently being developed. Here, we provide a concise overview of the core physiology of GLP-1 secretion and action, and the role of the peptide in human health, disease and therapeutics.
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