间充质干细胞
旁分泌信号
细胞生物学
干细胞
血管生成
细胞
再生(生物学)
癌症研究
生物
细胞外小泡
受体
生物化学
作者
Calvin Chang,Jerry Yan,Zhi Cheng Yao,Chi Zhang,Xiaowei Li,Hai‐Quan Mao
标识
DOI:10.1002/adhm.202001689
摘要
Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for tissue regeneration and remodeling due to their potent bioactivity, which includes modulation of inflammation response, macrophage polarization toward proregenerative lineage, promotion of angiogenesis, and reduction in fibrosis. This review focuses on profiling the effects of paracrine signals of MSCs, commonly referred to as the secretome, and highlighting the various engineering approaches to tune the MSC secretome. Recent advances in biomaterials-based therapeutic strategies for delivery of MSCs and MSC-derived secretome in the form of extracellular vesicles are discussed, along with their advantages and challenges.
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