硫酸乙酰肝素
佩莱肯
乙酰肝素酶
化学
蛋白多糖
癌症研究
间充质干细胞
糖胺聚糖
细胞外基质
作者
Zemin Ren,Marcel Spaargaren,Steven T. Pals
出处
期刊:Blood
[American Society of Hematology]
日期:2021-04-01
卷期号:137 (13): 1713-1718
被引量:2
标识
DOI:10.1182/blood.2020008188
摘要
Plasma cells no longer express a B-cell antigen receptor and are hence deprived of signals crucial for survival throughout B-cell development. Instead, normal plasma cells, as well as their malignant myeloma counterparts, heavily rely on communication with the bone marrow (BM) microenvironment for survival. The plasma cell heparan sulfate proteoglycan (HSPG) syndecan-1 (CD138) and HSPGs in the BM microenvironment act as master regulators of this communication by co-opting specific growth and survival factors from the BM niche. This designates syndecan-1/HSPGs and their synthesis machinery as potential treatment targets in multiple myeloma.
科研通智能强力驱动
Strongly Powered by AbleSci AI